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Aromatase inhibitors in men: effects and therapeutic options

Willem de Ronde1 and Frank H de Jong2*

Author Affiliations

1 Department of Internal Medicine, Kennemer Gasthuis, P.O. Box 417, 2000 AK Haarlem, The Netherlands

2 Department of Internal Medicine, Erasmus university Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands

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Reproductive Biology and Endocrinology 2011, 9:93  doi:10.1186/1477-7827-9-93

Published: 21 June 2011


Aromatase inhibitors effectively delay epiphysial maturation in boys and improve testosterone levels in adult men Therefore, aromatase inhibitors may be used to increase adult height in boys with gonadotropin-independent precocious puberty, idiopathic short stature and constitutional delay of puberty. Long-term efficacy and safety of the use of aromatase inhibitors has not yet been established in males, however, and their routine use is therefore not yet recommended.