Table 3

Results from studies assessing the association between 1st trimester sFlt-1 concentrations (pg/mL) and preeclampsia (PE)

Reference

Mean GA

Outcome

Cases (Preeclampsia)

Controls (normotensive)

P-value

% difference†



n

Flt-1 concentration

n

sFlt-1 concentration


Studies reporting mean concentrations

mean, SD/SE

mean, SD/SE

Baumann, 2008

12.3

PE (> 34 weeks)

46

1764 (757)

92

1537 (812)

0.04

+13

Chaiworapongsa, 2005

12.3

PE

34

546 (271)

37

464 (260)

0.10

+15

Lynch, 2010

12.3

PE

31

1374 (639)

637

1313 (521)

0.5

+5

Noori, 2010

13.7

PE (< 37 weeks)

10

2414 (622)

128

1729 (85)

< 0.01

+40

PE (≥ 37 weeks)

10

1688 (210)

128

1729 (85)

0.19

- 2

Rana S, 2007

11-13*

PE

39

3500 (300)

147

3000 (100)

0.14

+14

Thadhani, 2004

10.7

PE

40

1048 (657)

80

973 (490)

> 0.05

+ 7

Vatten, 2007

9.0

Preterm PE

110

135

276

166

0.01

-19

Studies reporting median concentrations

median

median

Akolekar 2010

11-13*

PE (< 34 weeks)

30

7099

180

6349

NS

+12

PE (≥ 34 weeks)

60

6840

180

6349

NS

+ 8

Erez, 2008

12.2

PE (< 37 weeks)

17

1308

201

1788

0.03

-27

12.2

PE (≥ 37 weeks)

39

1448

201

1788

0.02

-19

Wathen, 2006

13.7

PE

44

481

51

432

> 0.05

+10


*No mean gestational age (GA) provided

† % difference in case mean or median 1st trimester sFLT-1 compared with the control level

Jacobs et al. Reproductive Biology and Endocrinology 2011 9:77   doi:10.1186/1477-7827-9-77

Open Data