Table 1

Characteristics of studies assessing sFlt-1 in first trimester of pregnancy

Reference

Location

Study Design

Type of sample and gestational age at screening

Participants

Outcome(s)

s-FLT1

Summary measure


Akolekar, 2010

United Kingdom

nested case-control

Plasma

11-13 weeks

Singleton pregnancies

Exclusions: hypertension but uncertainty about a diagnosis of preeclampsia (n = 30), preeclampsia but stored blood not available (n = 57)

Preeclampsia

< 34 weeks

≥ 34 weeks

median

Baumann, 2008

Switzerland

case-control

Serum

11-14 weeks

Singleton pregnancies

Exclusions: women with history of hypertensive disorders, immunological diseases, HELLP, or PE < 34 weeks

Preeclampsia

mean, median

Chaiworapongsa, 2005

Chile

case-control

Plasma

7-16 weeks

Singleton pregnancies. Exclusions: pregnancies with fetal anomaly or demise, vaginal bleeding, women with serious medical conditions, chronic hypertension, asthma requiring medication, or requiring the use of anti-platelet or non-steroidal anti-inflammatory drug.

Preeclampsia

mean

Erez, 2008

Chile

nested case-control

Plasma

6-15 weeks

Singleton pregnancies.

SGA,

Preeclampsia (preterm and term)

median, OR

Eskild, 2008

Norway

nested case-control

Serum

4-12 weeks

Normotensive pregnant women only.

Excessive postpartum bleeding

mean

Lynch 2010

USA

2005-2008

prospective cohort

Serum

10-15 weeks

Singleton pregnancies, women presenting for prenatal care

Exclusions: intrauterine fetal loss, gestational hypertension

Preeclampsia

mean

Noori 2010

United Kingdom

prospective cohort

Serum

10-17 weeks

Singleton pregnancies from routine screening (n = 114) and an obstetric medicine clinic (n = 45)

Preeclampsia, (preterm and term)

Gestational hypertension

geometric mean

Rana S, 2007

USA,

2001-2003

nested case-control

Serum

11-13 weeks

Singleton pregnancies delivered > 20 weeks (livebirths) gestation.

Exclusions: women with history of hypertension, hypertension 6 weeks postpartum, renal disease, or diabetes.

Preeclampsia,

mean

Smith, 2007

Scotland,

1997-99

nested case-control

Serum

10-14 weeks

Singleton pregnancies.

Exclusions: stillbirths due to congenital anomalies or rhesus disease.

Preeclampsia

SGA

Preterm (extreme and moderate)

Stillbirth

OR

Thadhani R, 2004

USA,

2001-2003

nested case-control

Serum

8-14 weeks

Singleton pregnancies > 20 weeks gestation.

Exclusions: women with hypertension > 6 weeks postpartum, history of thyroid, liver, or chronic renal disease, or chronic hypertension.

Preeclampsia, Gestational hypertension

SGA

mean

Vatten LJ, 2007

Norway,

1992-1994

nested case-control

Serum

4-12 weeks

Singleton pregnancies

Preeclampsia (preterm and term)

mean, OR

Wathen KA, 2006

Finland,

2001-2002

longitudinal case-control

Serum

2-15 weeks

Singleton pregnancies among Caucasian women

Exclusions: women with history of hypertension, diabetes, chronic disease, or smoke > 5 cigarettes/day.

Preeclampsia

IUGR

median, OR


All blood testing done using an ELISA testing kit developed by R&D Systems

SGA = small for gestational age; IUGR = intrauterine growth restriction

Jacobs et al. Reproductive Biology and Endocrinology 2011 9:77   doi:10.1186/1477-7827-9-77

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