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Open Access Methodology

Clinical, genetic, and pathological features of male pseudohermaphroditism in dog

Enrico Bigliardi1*, Pietro Parma3, Paolo Peressotti2, Lisa De Lorenzi3, Peter Wohlsein4, Benedetta Passeri1, Stefano Jottini1 and Anna Maria Cantoni1

Author Affiliations

1 Faculty of Veterinary Medicine, Department of Animal Health, Parma, Italy

2 Private Clinics, Parma, Italy

3 Faculty of Agronomy, Department of Animal Science, Milan, Italy

4 University of Veterinary Medicine Hannover, Department of Pathology, Germany

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Reproductive Biology and Endocrinology 2011, 9:12  doi:10.1186/1477-7827-9-12

Published: 21 January 2011

Abstract

Male pseudohermaphroditism is a sex differentiation disorder in which the gonads are testes and the genital ducts are incompletely masculinized. An 8 years old dog with normal male karyotype was referred for examination of external genitalia abnormalities. Adjacent to the vulva subcutaneous undescended testes were observed. The histology of the gonads revealed a Leydig and Sertoli cell neoplasia. The contemporaneous presence of testicular tissue, vulva, male karyotype were compatible with a male pseudohermaphrodite (MPH) condition.