Table 5 |
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|
Genes > 2 fold up- or down-regulated after hormone treatment in HEC1A and/or RL95-2 cell line |
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|
Up-regulation > 2 fold |
ChIP target post E2 treatment |
ChIP target post P4 treatment |
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|
|
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|
HEC1A |
Molecular function* |
E2 |
P4 |
||
|
MEF2D |
Other transcription factor; Nucleic acid binding |
6 h |
HEC1A ERβ |
3 h |
RL95-2 PRB |
|
RL95-2 |
E2 |
P4 |
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|
CD86 |
Immunoglobulin receptor family member; Membrane-bound signaling molecule; Defense/immunity protein |
3 h |
HEC1A ERα |
NS |
ND |
|
MEF2D |
Other transcription factor; Nucleic acid binding |
3 h |
HEC1A ERβ |
3 h |
RL95-2 PRB |
|
OTOF |
Otoferlin |
12 h |
HEC1A ERα and ERβ |
3 h |
HEC1A PRA |
|
PLXNA2 |
Tyrosine protein kinase receptor;Protein kinase |
3 h |
RL95-2 ERβ |
3 h |
RL95-2 PRA |
|
RELB |
Other transcription factor |
3 h |
HEC1A ERα |
NS |
ND |
|
SMARCA2 |
DNA helicase |
3 h |
RL95-2 ERα |
3 h |
ND |
|
TNC |
Cell adhesion molecule; Extracellular matrix glycoprotein |
3 h |
HEC1A ERβ |
3 h |
RL95-2 PRA |
|
Down-regulation > 2 fold |
|||||
|
HEC1A |
Molecular function* |
E2 |
P4 |
||
|
CD86 |
Immunoglobulin receptor family member; Membrane-bound signaling molecule; Defense/immunity protein |
6 h |
HEC1A ERα |
NS |
ND |
|
FOXA2 |
Other transcription factor; Nucleic acid binding |
3 h |
RL95-2 ERβ |
12 h |
ND |
|
MMP7 |
Metalloprotease; Other extracellular matrix |
12 h |
HEC1A ERα and ERβ |
12 h |
ND |
|
NCOA1 |
Transcription factor; Acetyltransferα se |
3 h |
ND |
6 h |
RL95-2 PRA |
|
RELB |
Other transcription factor |
3 h |
HEC1A ERα |
6 h |
ND |
|
TNC |
Cell adhesion molecule; Extracellular matrix glycoprotein |
3 h |
HEC1A ERβ |
6 h |
RL95-2 PRA |
|
ZNF549 |
KRAB box transcription factor |
HEC1A ERα and ERβ |
6 h |
RL95-2 PRA |
|
|
RL95-2 |
E2 |
P4 |
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|
CD86 |
Immunoglobulin receptor family member; Membrane-bound signaling molecule; Defense/immunity protein |
12 h |
HEC1A ERα |
NS |
ND |
|
IHH |
Other signaling molecule; Protease |
12 h |
HEC1A ERα/ERβ |
6 h |
RL95-2 PRB |
|
|
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|
(*) Molecular functions were obtained from PANTHER. In bold are genes with cell line-specific expression. NS: not significant gene expression, ND: not detected. Official gene symbols according to HUGO Gene Nomenclature Committee (HGNC). |
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|
Tamm et al. Reproductive Biology and Endocrinology 2009 7:150 doi:10.1186/1477-7827-7-150 |
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