Table 1

some of the key factors regulating EVT cell functions

Factors

Source

Effect

Ref.


Proliferation

Migration

Invasiveness


Adhesion molecules

Trophoblast

↑↓

↑↓

53

Angiopoietins

Decidua, trophoblast

36

Colony Stimulating Factor-1

Placenta, decidua

59

Decorin

Decidua

60

Epidermal Growth Factor

Decidua, trophoblast

61

Endothelin

Placental blood vessels, CT, ST, EVT

62

Hepatocyte Growth Factor

Decidua, trophoblast

63

Insulin-like Growth Factor II

Trophoblast

64,65

Insulin-like Growth Factor Binding Protein-1

Decidua

64,65

Melanoma Cell Adhesion Molecule

Uterine smooth muscle cells

66

Metalloproteinases

Trophoblast

67

Nodal

Placenta

68

Hypoxia

↑↓

54,55

Urokinase-type Plasminogen Activator

Trophoblast

69

Prostaglandin E2

Decidua, trophoblast

57

58

8-iso-PGF

Decidua

70

Placental Growth Factor

Trophoblast

71

TGF-β

Decidua, trophoblast, uNK cells

61,64

TNF-α

Decidua, uNK cells, decidual macrophages

72

VEGF

Decidua, trophoblast

73


Lunghi et al. Reproductive Biology and Endocrinology 2007 5:6   doi:10.1186/1477-7827-5-6

Open Data