Schematic representation of cytotrophoblast (CT) differentiation to syncytiotrophoblast (ST) or extravillous trophoblast (EVT), together with some of the key factors involved in the control of these events. The box on the left lists factors stimulating CT proliferation, thus inhibiting differentiation. Boxes on the right list factors stimulating or inhibiting ST or EVT cell formation.
Lunghi et al. Reproductive Biology and Endocrinology 2007 5:6 doi:10.1186/1477-7827-5-6