Promoter and regulators elements of the transcriptional of human and mouse TERT. CpG island in human and mouse TERT promoter identify using the CpG Island Explorer Program at http://www.bioinfo.hku.hk/cpgieintro.html webcite are indicated in red line (A). Construct 5 k contain 4.5 Kb of the mouse promoter region, construct 1 k contains the proximal region of the promoter where all the transcription activator elements of the promoter reside (4 regions of c-Myc binding and two regions recognized by proteins from the sp1 family) and construct 2 k, includes, in addition to this proximal region, two of the three regions of MZF2 (myeloid zinc finger protein) binding, that reduces the transcriptional activity of the promoter (B).
Pericuesta et al. Reproductive Biology and Endocrinology 2006 4:5 doi:10.1186/1477-7827-4-5