|
Differentially expressed genes in the lung according to sex at GDs 15.5, 16.5 and 17.5 |
|||||||
| Id* |
Accession number |
Gene name† |
Fold changes‡ |
||||
|
|
|||||||
| Symbol |
GD15.5 (62)§ |
GD16.5 (33) |
GD17.5 (38) |
Chr. |
|||
|
|
|||||||
| Apoptosis |
|||||||
| #1 |
BI662863 |
Rho-associated coiled-coil forming kinase 1 |
Rock1 |
2.25 |
|||
| #2 |
NM_011997 |
caspase 8 associated protein 2 |
Casp8ap2 |
2.15 |
4 11.4 cM |
||
| Cell adhesion |
|||||||
| #3 |
NM_009925 |
procollagen, type X, alpha 1 |
Col10a1 |
M |
10 22.0 cM |
||
| #4 |
L20232 |
integrin binding sialoprotein |
Ibsp |
M |
5 56.0 cM |
||
| #5 |
NM_031163 |
procollagen, type II, alpha 1 |
Col2a1 |
2.96 |
F |
15 54.5 cM |
|
| #6 |
NM_007729 |
procollagen, type XI, alpha 1 |
Col11a1 |
2.25 |
3 53.1 cM |
||
| #7 |
AK004383 |
procollagen, type IX, alpha 1 |
Col9a1 |
1.96 |
1 15.0 cM |
||
| #8 |
U08020 |
procollagen, type I, alpha 1 |
Col1a1 |
(1.77) |
11 56.0 cM |
||
| Cell growth |
|||||||
| #9 |
NM_008341 |
insulin-like growth factor binding protein 1 |
Igfbp1 |
M |
11 1.3 cM |
||
| Coagulation |
|||||||
| #10 |
NM_008877 |
plasminogen |
Plg |
F |
F |
17 7.3 cM |
|
| #11 |
AK011118 |
fibrinogen, B beta polypeptide |
Fgb |
F |
F |
3 48.2 cM |
|
| #12 |
NM_133862 |
fibrinogen, gamma polypeptide |
Fgg |
(3.81) |
F |
3 41.3 cM |
|
| #13 |
BC005467 |
fibrinogen, alpha polypeptide |
Fga |
(3.10) |
F |
3 44.8 cM |
|
| #14 |
NM_010168 |
coagulation factor II |
F2 |
(2.67) |
2 47.5 cM |
||
| Endopeptidase activity |
|||||||
| #15 |
BC012874 |
serine (or cysteine) proteinase inhibitor, clade A, member 1a |
Serpina1a |
F |
F |
12 51.0 cM |
|
| #16 |
NM_007443 |
alpha 1 microglobulin/bikunin |
Ambp |
F |
F |
4 30.6 cM |
|
| #17 |
NM_010582 |
inter-alpha trypsin inhibitor, heavy chain 2 |
Itih2 |
F |
F |
2 1.0 cM |
|
| #18 |
NM_008407 |
inter-alpha trypsin inhibitor, heavy chain 3 |
Itih3 |
F |
F |
||
| #29 |
NM_007618 |
serine (or cysteine) proteinase inhibitor, clade A, member 6 |
Serpina6 |
(2.66) |
F |
12 51.0 cM |
|
| #20 |
NM_019429 |
protease, serine, 16 (thymus) |
Prss16 |
(2.65) |
13 10.0 cM |
||
| Erythroid-associated |
|||||||
| #21 |
NM_013848 |
erythroblast membrane-associated protein |
Ermap |
F |
4 57.0 cM |
||
| #22 |
AF069311 |
Rhesus blood group CE and D |
Rhced |
F |
4 65.7 cM |
||
| #23 |
NM_053149 |
hemogen |
Hemgn |
(3.29) |
F |
F |
|
| #24 |
NM_010635 |
Kruppel-like factor 1 (erythroid) |
Klf1 |
(3.01) |
|||
| #25 |
NM_133245 |
erythroid associated factor |
Eraf |
(2.38) |
|||
| #26 |
NM_010369 |
glycophorin A |
Gypa |
(2.27) |
8 36.0 cM |
||
| #27 |
AJ007909 |
erythroid differentiation regulator 1 |
Erdr1 |
(1.75) |
|||
| Hormone metabolism/regulation |
|||||||
| #28 |
NM_008293 |
hydroxysteroid dehydrogenase-1, delta<5>-3-beta |
Hsd3b1 |
M |
3 49.1 cM |
||
| #29 |
AV021656 |
aldo-keto reductase family 1, member B7 |
Akr1b7 |
M |
6 14.0 cM |
||
| #30 |
NM_009995 |
cytochrome P450, family 21, subfamily a, polypeptide 1 |
Cyp21a1 |
M |
|||
| #31 |
AI195150 |
group specific component |
Gc |
F |
F |
5 44.0 cM |
|
| #32 |
BG141874 |
transthyretin |
Ttr |
(3.93) |
F |
F |
18 7.0 cM |
| #33 |
NM_031192 |
renin 1 structural |
Ren1 |
3.67 |
F |
||
| #34 |
NM_007423 |
alpha fetoprotein |
Afp |
(2.64) |
F |
5 50.0 cM |
|
| #35 |
U63146 |
retinol binding protein 4, plasma |
Rbp4 |
(1.89) |
(2.16) |
19 38.0 cM |
|
| Immune functions |
|||||||
| #36 |
NM_011558 |
T-cell receptor gamma, variable 4 |
Tcrg-V4 |
F |
F |
F |
|
| #37 |
NM_009019 |
recombination activating gene 1 |
Rag1 |
F |
F |
2 56.0 cM |
|
| #38 |
M58149 |
CD3 antigen, gamma polypeptide |
Cd3g |
F |
F |
9 26.0 cM |
|
| #39 |
AF119253 |
histocompatibility 2, class II antigen A, alpha |
H2-Aa |
F |
|||
| #40 |
AV058500 |
P lysozyme structural |
Lzp-s |
3.42 |
1.70 |
||
| #41 |
X67128 |
T-cell receptor beta, variable 13 |
Tcrb-V13 |
(1.97) |
F |
F |
6 20.5 cM |
| #42 |
BC011474 |
lymphocyte protein tyrosine kinase |
Lck |
(2.87) |
4 59.0 cM |
||
| #43 |
BC003476 |
Ia-associated invariant chain |
Ii |
(2.10) |
18 32.0 cM |
||
| Lipid metabolism |
|||||||
| #44 |
NM_013475 |
apolipoprotein H |
Apoh |
F |
F |
11 63.0 cM |
|
| #45 |
NM_009692 |
apolipoprotein A-I |
Apoa1 |
F |
F |
9 27.0 cM |
|
| #46 |
NM_009695 |
apolipoprotein C-II |
Apoc2 |
(3.20) |
F |
7 4.0 cM |
|
| #47 |
NM_013474 |
apolipoprotein A-II |
Apoa2 |
(2.27) |
F |
1 92.6 cM |
|
| #48 |
BC002148 |
fatty acid binding protein 4, adipocyte |
Fabp4 |
2.33 |
3 13.9 cM |
||
| #49 |
BG922397 |
p47 protein |
p47 |
1.84 |
|||
| Protein biosynthesis |
|||||||
| #50 |
NM_012011 |
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked |
Eif2s3y |
M |
M |
M |
|
| #51 |
NM_009079 |
ribosomal protein L22 |
Rpl22 |
1.86 |
|||
| #52 |
AI642440 |
ribosomal protein S13 |
Rps13 |
(1.81) |
|||
| Signal transduction |
|||||||
| #53 |
X67702 |
secretoglobin, family 1A, member 1 (uteroglobin) |
Scgb1a1 |
M |
|||
| #54 |
BF537798 |
receptor (calcitonin) activity modifying protein 2 |
Ramp2 |
2.07 |
2.16 |
11 61.5 cM |
|
| #55 |
NM_016721 |
IQ motif containing GTPase activating protein 1 |
Iqgap1 |
1.96 |
7 39.0 cM |
||
| Transcriptionnal regulation |
|||||||
| #56 |
AA210261 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked |
Ddx3y |
M |
M |
M |
Y 2.07 cM |
| #57 |
AF127244 |
jumonji, AT rich interactive domain 1D (Rbp2 like) |
Jarid1d |
M |
M |
M |
Y 2.03 cM |
| #58 |
AA617392 |
Max protein |
Max |
F |
12 32.0 cM |
||
| #59 |
BB393998 |
flap structure specific endonuclease 1 |
Fen1 |
3.70 |
(2.96) |
||
| #60 |
NM_007496 |
AT motif binding factor 1 |
Atbf1 |
(2.16) |
8 E1 |
||
| Transport |
|||||||
| #61 |
BC024643 |
albumin 1 |
Alb1 |
(2.71) |
(8.68) |
5 50.0 cM |
|
| #62 |
AF440692 |
Transferring |
Trf |
(2.02) |
(3.29) |
9 56.0 cM |
|
| #63 |
BB448377 |
solute carrier family 4 (anion exchanger), member 1 |
Slc4a1 |
(2.07) |
11 62.0 cM |
||
| #64 |
NM_026331 |
mitochondrial solute carrier protein |
Mscp |
(1.90) |
|||
| Others |
|||||||
| #65 |
BB742957 |
ubiquitously transcribed tetratricopeptide repeat gene, Y chr. |
Uty |
M |
M |
M |
Y 2.06 cM |
| #66 |
AI256465 |
alpha-2-HS-glycoprotein |
Ahsg |
F |
F |
16 15.0 cM |
|
| #67 |
AK003182 |
myosin, light polypeptide 1 |
Myl1 |
F |
1 34.1 cM |
||
| #68 |
BG806300 |
inactive X specific transcripts |
Xist |
(3.34) |
(13.22) |
(2.41) |
X 42.0 cM |
| #69 |
AV224521 |
Gelsolin |
Gsn |
3.27 |
2 24.5 cM |
||
| #70 |
NM_025711 |
Asporin |
Aspn |
2.72 |
|||
| #71 |
BC002136 |
coronin, actin binding protein 1A |
Coro1a |
(2.48) |
7 62.5 cM |
||
| #72 |
AK017440 |
RNA imprinted and accumulated in nucleus |
Rian |
(2.27) |
12 54.5 cM |
||
| #73 |
AV156640 |
expressed in non-metastatic cells 1, protein |
Nme1 |
2.23 |
|||
| #74 |
AF291655 |
Tenomodulin |
Tnmd |
2.12 |
|||
| #75 |
BB745314 |
male-specific lethal-2 homolog (Drosophila) |
Msl2 |
(2.11) |
|||
| #76 |
BB490338 |
calponin 3, acidic |
Cnn3 |
2.04 |
|||
| #77 |
BB475271 |
LUC7-like 2 (S. cerevisiae) |
Luc7l2 |
1.96 |
|||
| #78 |
NM_053123 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 |
Smarca1 |
1.93 |
|||
| #79 |
BM207360 |
unc-50 homolog (C. elegans) |
Unc50 |
1.91 |
|||
| #80 |
AV011848 |
malate dehydrogenase 1, NAD (soluble) |
Mdh1 |
1.89 |
11 12.0 cM |
||
| #81 |
AA270173 |
Lamin B1 |
Lmnb1 |
(1.89) |
18 29.0 cM |
||
| #82 |
BB192717 |
protein phosphatase 2 (formerly 2A), reg. subunit A (PR 65), alpha isoform |
Ppp2r1a |
(1.88) |
|||
| #83 |
BE372352 |
ARP3 actin-related protein 3 homolog (yeast) |
Actr3 |
1.77 |
|||
| Unknowns |
|||||||
| #84 |
AA717264 |
Transcribed sequences |
2.51 |
||||
| #85 |
BC021831 |
CDNA clone MGC:67258 IMAGE:6413648, complete cds |
(2.14) |
(2.36) |
|||
| #86 |
AK018316 |
DNA segment, Chr 2, ERATO Doi 145, expressed |
D2Ertd145e |
2.31 |
2 31.0 cM |
||
| #87 |
BE865094 |
expressed sequence AI448196 |
AI448196 |
(2.14) |
|||
| #88 |
BB151477 |
RIKEN cDNA 2810468K05 gene |
2810468K05Rik |
1.88 |
|||
|
*- Identification numbers of genes found in this study. †- Genes are presented in only one functional category although some of them could have been placed in more than one category. ‡- Values with no bracket correspond to higher levels for males, while values in brackets correspond to higher levels for females. The letter M (Male) or F (Female) replace the fold change value when the gene was expressed in one sex only. §- The number of genes differentially expressed at each gestational day (GD) is indicated. | |||||||
Simard et al. Reproductive Biology and Endocrinology 2006 4:25 doi:10.1186/1477-7827-4-25 |
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