Table 1

Chromosomal location and dose effects. Several genes involved in mammalian sex determination have dose effects leading to sex reversal.

Chromosomal location

Gene

Number of copies

Phenotype

Reference


Y Chromosome

SRY

0

Female

1

Male

[12]

X Chromosome

Dax-1

1

Normal

2

Female XY

[13]

Autosomal

Sox9

1

Female XY

[14,15]

Masculinizing

2

Normal

3

Male XX

[16]

Autosomal

SF-1

1

Female XY

[17]

Masculinizing

2

Normal

Autosomal

WT1

1

Female XY

[18]

Masculinizing

2

Normal

Autosomal

Dmrt1

1

Female XY

[19]

Masculinizing

2

Normal


von Hofsten and Olsson Reproductive Biology and Endocrinology 2005 3:63   doi:10.1186/1477-7827-3-63

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