Involvement of a hierarchy of genes in mammalian sex determination and differentiation. In XY/XX systems where SRY is the key regulator of sex determination its absence leads to activation of Dax1 and female development. The presence of SRY results in a hierarchy of activation of genes leading to the development of testis. In this hierarchy SF-1 (FTZ-F1) is a key regulator of steroidogenesis and AMH, demonstrating its central role in sex determination and differentiation. ⊥: Inhibition, ↓: stimulation.
von Hofsten and Olsson Reproductive Biology and Endocrinology 2005 3:63 doi:10.1186/1477-7827-3-63