General structure of zebrafish FTZ-F1 proteins. The zebrafish FTZ-F1 proteins consist of four main regions, the modulator domain, DNA-binding domain (DBD), hinge region and the ligand-binding domain. The DBD contains a Zink-finger region, an A- and P-box for recognition of the FTZ-F1 response element, and a T-box for stabilising the DNA-binding. The proximal repressive- and interactive domains (PRD and PID) are used for interactions with co-repressors and co-activators. The ligand binding-domain containing the I-box and AF-2 region, which both are involved in ligand binding and transactivation, and a distal repressive domain (DRD) for co-repressor binding.
von Hofsten and Olsson Reproductive Biology and Endocrinology 2005 3:63 doi:10.1186/1477-7827-3-63