Table 1

Overview of ligands, both endogenous and exogenous, for the PPAR isotypes. Asterisks denote presence in the ovary, and/or reported affect on ovarian cells.
Endogenous Ligands	Source	Specificity for PPAR isotype	Reference

Polyunsaturated fatty acids*	Diet Metabolism	PPARα>PPARδ>>PPARγ	[25]; reviewed in [5]
Eicosanoids*	Inflammation	PPARα, PPARδ, PPARγ	[25]
8-HETE	Metabolism	PPARα
PGJ₂		PPARγ>>>PPARα>PPARδ	[17] [26]
PGA₁		PPARδ>>PPARα,PPARγ	[17] [25]
PGI₂		PPARδ	reviewed in [16]
Leukotriene B₄		PPARα	[23] [25]
Lysophosphatidic acid*	Metabolism	PPARγ	[18]
Oxidized LDL	Metabolism	PPARγ	reviewed in [29]

Exogenous Ligands	Source	Specificity for PPAR isotype	Reference

Herbicides/fungicides	Environment	PPARγ	[19]; reported in [1]
Plasticizers*	Environment Industry		[137]; reviewed in [15]
NSAIDS	Pharmaceutical	PPARγ>PPARα>>PPARδ	[20] [28]
Fibrates*	Pharmaceutical	PPARα>>>PPARγ	[25]
Polycyclic aromatic hydrocarbons	Environment	PPARα, PPARδ	[21]
Herbal/plant compounds	Traditional medicine	PPARα, PPARγ>PPARδ	reviewed in [14]
Genistein*	Plants	PPARγ	[138]
Thiazolidinediones*	Pharmaceutical	PPARγ	[23] [55]

Komar Reproductive Biology and Endocrinology 2005 3:41 doi:10.1186/1477-7827-3-41