Research

Prevalence of ultrasonography proved polycystic ovaries in North Indian women with type 2 diabetes mellitus

Abdul H Zargar , Vipin K Gupta , Arshad I Wani , Shariq R Masoodi , Mir I Bashir , Bashir A Laway , Mohammad A Ganie and Mohammad Salahuddin

Departments of Endocrinology and Immunology, Sheri-Kashmir Institute of Medical Sciences Srinagar, J&K, India

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Reproductive Biology and Endocrinology 2005, 3:35doi:10.1186/1477-7827-3-35

Published:	11 August 2005

Abstract

Background

Polycystic ovaries (PCO) and their clinical expression (the polycystic ovary syndrome [PCOS]) as well as type 2 diabetes mellitus (T2DM) are common medical conditions linked through insulin resistance. We studied the prevalence of PCO and PCOS in women with diet and/or oral hypoglycemic treated T2DM and non-diabetic control women.

Design

Prospective study.

Methods

One hundred and five reproductive age group women with diet and /or oral hypoglycemic treated T2DM were the subjects of the study. Sixty age-matched non-diabetic women served as controls. Transabdominal ultrasonographic assessment of the ovaries was used to diagnose PCO. Clinical, biochemical and hormonal parameters were also noted.

Results

Ultrasonographic prevalence of PCO was higher in women with diabetes than in non-diabetic subjects (61.0% vs. 36.7%, P < 0.003) whereas that of PCOS was 37.1% in diabetic subjects and 25% in non-diabetic controls (P > 0.1). Diabetic women with PCO had diabetes of significantly longer duration than those without PCO (4.19±2.0 versus 2.9±1.6 yrs; p < 0.05). Among both diabetic and non-diabetic women, those with PCO had significantly higher plasma LH, LH/FSH ratio, total testosterone and androstenedione levels.

Conclusion

This study demonstrates a higher prevalence of PCO in women with T2DM as compared to non-diabetic subjects.