|
Effect of PGF2α on the expression of genes related to the extracellular matrix (ECM). |
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| Gene Bank number |
Swiss protein number |
Name |
Function |
Ratio |
% decrease |
Fold increase |
|
|
||||||
| U65656 |
P97581 |
Gelatinase A |
Metalloproteinase |
0.04 ± 0.02 |
87.53 |
|
| Y00697 |
P07154 |
Cathepsin L |
Cysteine protease |
0.09 ± 0.05 |
91.09 |
|
| L31884 |
P30121 |
Tissue inhibitor metalloproteinase 2 (TIMP2) |
Protease inhibitor |
0.05 ± 0.01 |
95.54 |
|
| U27201 |
P48032 |
Tissue inhibitor metalloproteinase 3 (TIMP3) |
Protease inhibitor |
0.04 ± 0.01 |
91.95 |
|
| X63434 |
P29598 |
Urokinase type Plasminogen activator (uPA) |
Serine protease |
0.14 ± 0.09 |
94.86 |
|
| M24067 |
P20961 |
Plasminogen activator inhibitor (PAI) |
Protease inhibitor |
0.09 ± 0.05 |
91.68 |
|
| M2367 |
P19367 |
Tissue type plasminogen activator (tPA) |
Serine protease |
0.17 ± 0.02 |
89.90 |
|
| X71071 |
Q08290 |
Calponin |
Cytoskeleton |
0.08 ± 0.004 |
92.50 |
|
| U06755 |
P37397 |
Calponin, acidic |
Cytoskeleton |
0.24 ± 0.13 |
76.76 |
|
| U62897 |
O35850 |
Carboxypeptidase D |
Carboxypeptidase |
0.24 ± 0.14 |
76.48 |
|
| M64711 |
P22388 |
Endothelin 1 |
Hormone |
0.34 ± 0.2 |
77.48 |
|
| X02601 |
P03957 |
Polypeptide, 53 kDa, growth factor induced |
Metalloproteinase |
2.54 ± 1.04 |
3 |
|
| J03552 |
P14046 |
Plasma proteinase inhibitor α1-inhibitor III |
Protease inhibitor |
3.64 ± 0.64 |
4 |
|
| M32247 |
P17475 |
α1 antiproteinase |
Protease inhibitor |
2.45 ± 0.44 |
3 |
|
|
Ratio = net intensity of PGF2α normalized/net intensity of control normalized, and represent the mean ± SEM of each ratio from separate experiments. Ratio > 2 = up regulation; ratio < 0.5 = down regulation; 0.5 < Ratio < 2 = equal expression. | ||||||
Callegari et al. Reproductive Biology and Endocrinology 2005 3:3 doi:10.1186/1477-7827-3-3 |
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