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Basic Properties of Prostate Cell Lines. |
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| Cell Line |
Origin |
Androgen Responsiveness |
Tumorigenicity |
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| NbE1.4 [151-154] |
Normal rat ventral prostate |
Androgen sensitive |
None |
| P69 [148,149] |
Normal Human prostate |
Androgen independent |
Very poor |
| DU-145 [147] |
Human brain metastasis |
Androgen independent |
High |
| LNCaP [145] |
Human lymph node metastasis |
Androgen sensitive |
Low |
| C4-2* [113,144] |
Human castrated mice |
Androgen refractory |
High with bone metastases |
| VCaP [150] |
Human bone metastasis |
Androgen sensitive |
High |
| PC-3 [146] |
Human bone metastasis |
Androgen independent |
High |
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*This cell line was derived from the original co-inoculation of LNCaP and bone stromal cells in mice. References for each cell line are as follows: LNCaP (Lymph Node Carcinoma of the Prostate), PC-3 (Prostate Cancer-3), DU-145 (Dura-145), and VCaP (Vertebral-Cancer of the Prostate). | |||
Stewart et al. Reproductive Biology and Endocrinology 2004 2:2 doi:10.1186/1477-7827-2-2 |
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