  ReviewReactive oxygen species and sperm cellsDorota Sanocka  and Maciej Kurpisz  Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland  author email corresponding author email
Reproductive Biology and Endocrinology 2004,
2:12doi:10.1186/1477-7827-2-12 Abstract
There is a dynamic interplay between pro- and anti-oxidant substances in human ejaculate. Excessive reactive oxygen species (ROS) generation can overwhelm protective mechanism and initiate changes in lipid and/or protein layers of sperm plasma membranes. Additionally, changes in DNA can be induced. The essential steps of lipid peroxidation have been listed as well as antioxidant substances of semen. A variety of detection techniques of lipid peroxidation have been summarized together with the lipid components of sperm membranes that can be subjected to stress. It is unsolved, a threshold for ROS levels that may induce functional sperm ability or may lead to male infertility. | 
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