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Open Access Research

Can cycle day 7 FSH concentration during controlled ovarian stimulation be used to guide FSH dosing for in vitro fertilization?

Yaakov Bentov123*, Eliezer Burstein123, Courtney Firestone23, Ross Firestone23, Navid Esfandiari12 and Robert F Casper123

Author Affiliations

1 Toronto Centre for Advanced Reproductive Technology, Toronto, ON, Canada

2 Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada

3 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada

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Reproductive Biology and Endocrinology 2013, 11:12  doi:10.1186/1477-7827-11-12

Published: 22 February 2013

Abstract

Background

When stimulating a patient with poor ovarian response for IVF, the maximal dose of gonadotropins injected is often determined by arbitrary standards rather than a measured response. The purpose of this study was to determine if serum FSH concentration during an IVF stimulation cycle reflects follicular utilization of FSH and whether serum FSH values may inform dose adjustments of exogenous FSH.

Methods

In this retrospective cross sectional study we studied 155 consecutive IVF cycles stimulated only with recombinant human FSH. We only included long GnRH agonist protocols in which endogenous FSH levels were suppressed. We correlated the serum concentration of cycle day (CD) 7 FSH with the number of oocytes retrieved, cleaving embryos and pregnancy rate.

Results

We found that a CD7 FSH concentration above 22 IU/L was associated with poor response regardless of the daily dose of FSH injected and a lower pregnancy rate.

Conclusions

We concluded that CD7 FSH concentration during stimulation could be used to guide FSH dosing in poor responders. If the CD7 FSH concentration is above 22 IU/L increasing the dose of FSH in an attempt to recruit more growing follicles is unlikely to be successful.

Keywords:
Serum FSH concentration; FSH elimination; Poor ovarian response; In vitro fertilization; Ovarian stimulation