Research
PreImplantation Factor (PIF) promoting role in embryo implantation: increases endometrial Integrin-α2β3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua
Reproductive Biology and Endocrinology 2012, 10:50 doi:10.1186/1477-7827-10-50
alpha2beta3
Norman Sachs (2012-07-16 21:35) Hubrecht Inst
Dear Sir/Madam,
The obligate heterodimer for the integrin alpha2 is beta1. The integrin beta3 can to my knowledge only associate with alphaIIb or alphav. AlphaIIbbeta3 is a platelet receptor whereas alphavbeta3 is widely expressed and is most likely recognized by SSA6 in your FACS assays.
I suggest to recheck the use of alpha2beta3 in your manuscript or provide evidence for their direct association.
With kind regards,
Norman Sachs
Competing interests
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