Chemokines in the corpus luteum: Implications of leukocyte chemotaxis
Department of Animal and Nutritional Sciences, University of New Hampshire-Durham, Durham, NH 03824, USA
Reproductive Biology and Endocrinology 2003, 1:94 doi:10.1186/1477-7827-1-94Published: 10 November 2003
Chemokines are small molecular weight peptides responsible for adhesion, activation, and recruitment of leukocytes into tissues. Leukocytes are thought to influence follicular atresia, ovulation, and luteal function. Many studies in recent years have focused attention on the characterization of leukocyte populations within the ovary, the importance of leukocyte-ovarian cell interactions, and more recently, the mechanisms of ovarian leukocyte recruitment. Information about the role of chemokines and leukocyte trafficking (chemotaxis) during ovarian function is important to understanding paracrine-autocrine relationships shared between reproductive and immune systems. Recent advances regarding chemokine expression and leukocyte accumulation within the ovulatory follicle and the corpus luteum are the subject of this mini-review.