Table 2

Summary of some characteristics of the T regulatory cells

    T regulatory (TREG) cells

1. Definition

Cells with regulatory function that produce IL-10 and TGF-β and play a critical role in the control the immune response and the generation and maintenance of tolerance.

2. Properties

    heterogeneous group
of lymphocytes

• exist in

    very low numbers

    respond poorly
to stimulation through TCR

    unique and diverse mechanisms
of action

    none
common specific phenotypic marker

3. Some subtypes by phenotype

• CD4+CD25+

• CD4+CD45RB+

• CD8+

• TCRγδ+

• NT/NKT cells – e.g. Vα24-JαQ

• CTLA4+

4. Subtypes by cytokine profile

    Th3 cells
: differentiate from naive CD4+ or CD8+ cells under the influence of TGF-β, produce TGF-β > IL-10, varying IL-4

    Tr1 cells
: differentiate from naive CD4+ or CD8+ cells under the influence of IL-10, produce IL-10 > TGF-β, no IL-4


Mincheva-Nilsson Reproductive Biology and Endocrinology 2003 1:120   doi:10.1186/1477-7827-1-120

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