Table 1

Comparison between TCRγδ and TCRαβ lymphocytes

    Comparison between the γδT and αβT lymphocyte lineage

Characteristics

γδT lymphocytes

αβT lymphocytes

Resident

Circulating

Immunity affiliation

innate

innate/adaptive(?)

adaptive

Ontogeny

develop earlier

develop earlier

develop later

Development

thymus/ extra-thymus

thymus

thymus/extra-thymus

Ag-receptor configuration

CD3+Vδ1

CD3+Vδ2

CD3+TCRαβ

Phenotype

different from αβT cells

similar to αβT cells

CD4-/CD8- (most)

CD4-/CD8- (most)

CD4+ or CD8+

CD8+ or CD8αα (some)

MHC restriction

no

no

yes

Antigen recognition

self-antigens

non-peptide antigens from bacteria and plants

peptide+MHC

Frequency in blood

very few

1–10%

65–75%

Tissue distribution

mucosae, epithelia, lymphoid tissues

blood lymphoid tissues (?)

blood, lymphoid tissues, mucosae

Effector functions

cytotoxic potency

cytotoxic potency

cytotoxic potency

cytokine release

cytokine release

cytokine release (Th1/Th2)

Biological functions

immunoregulation

pathogen eradication

pathogen eradication

immunosurveillance

immune protection

pathogen eradication

wound repair (mice)


Mincheva-Nilsson Reproductive Biology and Endocrinology 2003 1:120   doi:10.1186/1477-7827-1-120

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