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Comparison between TCRγδ and TCRαβ lymphocytes |
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| Comparison between the γδT and αβT lymphocyte lineage |
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| Characteristics |
γδT lymphocytes |
αβT lymphocytes |
|
| Resident |
Circulating |
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| Immunity affiliation |
innate |
innate/adaptive(?) |
adaptive |
| Ontogeny |
develop earlier |
develop earlier |
develop later |
| Development |
thymus/ extra-thymus |
thymus |
thymus/extra-thymus |
| Ag-receptor configuration |
CD3+Vδ1 |
CD3+Vδ2 |
CD3+TCRαβ |
| Phenotype |
different from αβT cells |
similar to αβT cells |
|
| CD4-/CD8- (most) |
CD4-/CD8- (most) |
CD4+ or CD8+ |
|
| CD8+ or CD8αα (some) |
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| MHC restriction |
no |
no |
yes |
| Antigen recognition |
self-antigens |
non-peptide antigens from bacteria and plants |
peptide+MHC |
| Frequency in blood |
very few |
1–10% |
65–75% |
| Tissue distribution |
mucosae, epithelia, lymphoid tissues |
blood lymphoid tissues (?) |
blood, lymphoid tissues, mucosae |
| Effector functions |
cytotoxic potency |
cytotoxic potency |
cytotoxic potency |
| cytokine release |
cytokine release |
cytokine release (Th1/Th2) |
|
| Biological functions |
immunoregulation |
pathogen eradication |
pathogen eradication |
| immunosurveillance |
immune protection |
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| pathogen eradication |
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| wound repair (mice) |
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Mincheva-Nilsson Reproductive Biology and Endocrinology 2003 1:120 doi:10.1186/1477-7827-1-120 |
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