Review

Assessment of fetal intracranial pathologies first demonstrated late in pregnancy: cell proliferation disorders

Gustavo Malinger^1,2 , Dorit Lev^1,3 and Tally Lerman-Sagie^1,4

¹  Fetal Neurology Clinic, Edith Wolfson Medical Center, Holon & Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

²  Prenatal Diagnosis Unit, Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon & Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

³  Institute of Medical Genetics, Edith Wolfson Medical Center, Holon & Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

⁴  Pediatric Neurology Unit, Edith Wolfson Medical Center, Holon & Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Reproductive Biology and Endocrinology 2003, 1:110doi:10.1186/1477-7827-1-110

Published:	14 November 2003

Abstract

A considerable number of central nervous system pathologies remain undiagnosed during the first two trimesters of pregnancy. This group of disorders includes anomalies of brain proliferation, migration and cortical organization. Due to the fact that a detailed ultrasound examination of the fetal brain is usually not performed during the third trimester the diagnosis of these disorders is usually only made in families with a previously affected child or in many cases be mere chance. In this article we review the feasibility of prenatal diagnosis of disorders of brain proliferation: microcephaly, macrocephaly, hemimegalencephaly and neoplastic and non-neoplastic abnormal cell types. We discuss the differential diagnosis and offer a stepwise approach to the diagnosis of the more common disorders.